Name : Shereen Karam Zahyan Ragheb            

Date of Birth : 23/8/1982        

Nationality : Egyptian

Previous Degree : B.Sc.

Registration Date : 27/2/2005

Awarding Date : 17/2/2008

Supervisors :

  • Prof. Dr. Mohamed Mohamed Fathi                                

  • Prof. Dr. Samir El-deib Ibrahim

  • Prof. Dr. Seham Mahmoud Abdel Kader                         

Examiners :

  • Prof. Dr. Mohamed Mohamed Fathi                                

  • Prof. Dr. Nadia Mohamed Abdel Aziz El-Beih

  • Prof. Dr. Rupert Mutzel

Title of Thesis:

Effects of Some Herbal Plants on CNS GABA Content and Factors Regulating It in Albino Rat

Key Words: Zingiber officinale; Melissa officinalis; Calcium; Chloride; GABA; Inorganic Phosphate; Magnesium; Sodium.

Summary:

The current study aims to explore the effect of two commonly used herbal plants from different families; Melissa officinalis Linnaeus (lemon balm) and Zingiber officinale Roscoe (ginger), on the total content of GABA, free Pi and some ions (Na+, Ca2+, Mg2+ and Cl-) in different brain areas (cerebellum, pons+medulla, striatum, cortex, hypothalamus, mid-brain and hippocampus) of the adult male albino rats. A group of adult male albino rats was daily and orally administered 50 mg/kg of Melissa extract for 4 weeks, as well as, another group was daily and orally administered 50 mg/kg of Zingiber extract for 4 weeks, for each group its own control. The administration of Melissa extract resulted in a significant decrease in both GABA and free Pi content throughout the experimental period in different brain areas under investigation, with a significant decrease in total Na+ and Ca2+ content and a significant increase in total Mg2+ and Cl- content after 4 weeks, compared with its control group. On the other hand, the administration of Zingiber extract resulted in a significant increase in total GABA content in all tested brain areas, however, a significant decrease in total Pi content was observed in most brain areas under investigation throughout the experimental period, with a significant increase in total Na+ and Ca2+ content and a significant decrease in total Mg2+ and Cl- content after 4 weeks, compared with its control group. It was

concluded that, the effect of Melissa and Zingiber on GABA, free Pi and Na+, Ca2+, Mg2+ and Cl- content, may be due to the action of Melissa as a benzodiazepine compound and Zingiber as a psychostimulant, with other pharmacological properties attributed to their components.

 

 

 
 
 
 

 

  
 
   
   
   
 

 
   
   
   
   
   

 

 

  
   
   
   
   
   
   
   
   
   
   
   
 

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