Name :              Mahmoud Hany Khedr

Date of Birth:    12 April 1973

Nationality:        Egyptian

Previous Degree:              Ph.D

Registration Date:  July 2005

Awarding Date: February 2008

Supervisors

 Prof. Dr: Fadel Mohamed Ali               

Prof. Dr: Wafaa Mohamed Ahmed Khalil

Prof. Dr. Alia Hassan Abdel-Fattah 

Assist. Prof.  Dr. Reem Hassan El-Gebaly

Examiners:

      1-Prof, Dr Wafaa Mohamed Ahmed Khalil

2-Prof, Dr. Karl Buchtela

       3-Prof, Dr. M. Salih Celik

Title:

"Risk associating injection of patients with radiopharmaceuticals in Nuclear Cardiology" (in vivo and in vitro)

 

Key Words:

 

Risk - patients - radiopharmaceuticals - Nuclear Cardiology

Summary

The main purpose of the present work is to evaluate the risk associating injection with different radiopharmaceuticals on the red blood cells properties and functions. This was achieved through measurements of the solubilization of cell membrane with non ionic detergent, osmofragility studies and molecular properties of Hb through measurements of the dielectric relaxation absorption spectra and the morphological form of the RBCs through blood film as scanned by an image analyzer The radiopharmaceuticals used were ^99mTc, ^99mTc-MIBI ^99mTc-tetrofosmin and ²⁰¹Tl

The results of the blood characteristics for the patients after being injected with the radiopharmaceuticals indicated that, there are changes in the cellular membrane surface after injection this can be noticed from the solubilization curves, osmofragility curves and blood films. The degree of change in blood characteristics proved to be radiopharmaceutical type dependent.

 

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