Name :                 Mona Abdel-Fattah Mahmoud Abo-Zeid

Date of Birth :     9/10/1975

Nationality :         Egyptian

Previous Degree : Ph.D.

Registration Date : 1/12/2004

Awarding Date : 6/1/2008

Supervisors :        Prof. Dr. Mahmoud A. Amer

                              Prof. Dr. Fawzia A. Aly

 

Examiners :  Prof. Dr. I. Hansmann

                   Prof. Dr. D. M. Saxena

                   Prof. Dr. Mahmoud A. Amer

Title of Thesis :

“Role of the folic acid, vitamin B₁₂ and vitamin C in the inhibition of the mutagenicity of the anticancer drugs Daunorubicin and Ifosfamide in mice.”

Key Words :    Daunorubicin- Ifosfamide- Folic Acid- Vitamin B12- Vitamin C- Chromosomal Aberrations- SCE's- Sperm Shape Abnormalities- DNA Fragmentation.

Summary :

The present study indicates that the anticancer drugs DNR and IFO are mutagenic in mouse somatic and germ cells. Vitamins (FA, VB12 and VC) play a beneficial role against the mutagenicity of `these drugs.

 

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